HER4 or ERBB4 is a transmembrane receptor tyrosine kinase that belongs to epidermal growth factor receptor family (1). Through its interaction with its activating ligand heregulin, HER4 can regulate proliferation and differentiation of cells (2). HER4 ectodomain is cleaved by a metalloprotease, gamma-secretase that releases the HER4 intracellular domain from the membrane and facilitates its translocation to the nucleus. The kinase activity of HER4 is both necessary and sufficient to trigger an antiproliferative response in human breast cancer cells. Increased expression of HER4 has been detected in various cancers and this usually correlates to better survival.
ERBB4, MGC138404, p180erbB4
1. Carolyn, I. et al: HER4 Mediates Ligand-Dependent Antiproliferative and Differentiation Responses in Human Breast Cancer Cells. Mol.Cellular Biol., 2001, 21: 4265-4275.
2. Jorma, A. et al: Proteolytic Cleavage and Phosphorylation of a Tumor-associated ErbB4 Isoform Promote Ligand-independent Survival and Cancer Cell Growth. MolBiolCell, 2006; 17, 1: 67-79.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases