PTPRC (CD45) contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP (1). This gene is specifically expressed in hematopoietic cells (2). PTPRC has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling (3).
B220; Cd45; CD45R; loc; Ly-5; Lyt-4; T200
1. Ralph, S. J. et al: Structural variants of human T200 glycoprotein (leukocyte-common antigen). EMBO J. 6: 1251-1257, 1987.
2. Fischer, E. H. et al: Protein tyrosine phosphatases: a diverse family of intracellular and transmembrane enzymes. Science 253: 401-406, 1991.
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Invasion/Metastasis, Phosphatases