Home   >    Proteins   >   Protein Kinases

NDR, Active

Full-length recombinant human NDR was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S49-10G


Shop Online



Catalog No. Pack Size Price (USD)
S49-10G-05 5 ug $226
S49-10G-10 10 ug $325
S49-10G-BULK BULK Contact Us  


Overview:

NDR or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins (1). Fas and TNFα receptor stimulation activates human NDR by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade (2). NDR is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. NDR is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. NDR-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of NDR activity.


Gene Aliases:

NDR1, STK38


Genbank Number:


References:


1. Millward, T. et.al: Molecular cloning and characterization of a conserved nuclear serine (threonine) protein kinase. Proc. Nat. Acad. Sci. 92: 5022-5026, 1995.

2. Vichalkovski A. et al: NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol. 2008 Dec 9;18(23):1889-95.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~81 kDa



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Inflammation, Ser/Thr Kinases


RELATED PRODUCTS


  STK32B (YANK2), Active, Y04-10G

  NDR2, Active, S50-10G

  SGKtide, S08-58

  LKB1(STK11) Protein, L15-30G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox