Overview:

Guanine nucleotide-binding proteins (G proteins) are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits, and function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. G protein subunit alpha i1(GNAI1) represents the alpha subunit of an inhibitory complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase.

Gene Aliases:

Gi

Genbank Number:

NM_002069

References:

1. Selzer E, et al: Stimulation of human thyroid growth via the inhibitory guanine nucleotide binding (G) protein Gi: constitutive expression of the G-protein alpha subunit Gi alpha-1 in autonomous adenoma. Proc Natl Acad Sci U S A. 1993 Feb15;90(4):1609-13.

2. Bray P, et al: Human cDNA clones for an alpha subunit of Gi signal-transduction protein. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5115-9.