Overview:

Guanine nucleotide-binding proteins (G proteins) are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits, and function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. G protein subunit alpha i3 (GNAI3) stimulates the activity of receptor-regulated K+ channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.

Gene Aliases:

87U6; ARCND1

Genbank Number:

NM_006496

References:

1. Mattera R, et al: Recombinant alpha i-3 subunit of G protein activates Gk-gated K+ channels. J Biol Chem. 1989 Jan 5;264(1):465-71.

2. Cho H, et al: Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55.

3. http://www.uniprot.org/uniprot/P08754