LRRK1, also called leucine-rich repeat kinase 1, is highly expressed in testis, placenta, prostate, and muscle, with moderate expression in brain, pancreas, small intestine, stomach, and spleen. Mutations in LRRK1 corresponding to Parkinson disease-8 -associated mutations found in LRRK2, significantly reduced LRRK1 kinase activity (1). LRRK1 expression in all mouse brain regions examined, with highest expression in olfactory bulb (2). LRRK1 functions as a GDP/GTP-binding protein and its kinase activity is stimulated upon binding of GTP to the ROC domain.
RIPK6; Roco1; FLJ23119; KIAA1790
1. Korr, D.et.al: LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain. Cell. Signal. 18: 910-920, 2006.
2. Taylor, J. P.et.al: Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease. Neurogenetics 8: 95-102, 2007
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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