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PRKX, Active

Full-length recombinant human PRKX was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P81-10G


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Catalog No. Pack Size Price (USD)
P81-10G-05 5 ug $226
P81-10G-10 10 ug $325
P81-10G-BULK BULK Contact Us  


Overview:

PRKX is a serine/threonine protein kinase that is closely related to the catalytic subunit of the cAMP-dependent protein kinase. PRKX regulates epithelial morphogenesis during mammalian kidney development and PRKX expression markedly activates migration of cultured renal epithelial cells in the presence of cAMP. Aberrant adult kidney expression of PRKX is found in autosomal dominant polycystic kidney disease (1). PRKX is involved in macrophage and granulocyte maturation. Abnormal recombination between PRKX and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females (2).


Gene Aliases:

PKX1


Genbank Number:


References:


1. Li, X. et al: PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis. Proc. Nat. Acad. Sci. vol. 99, 9260-9265, 2002.

2. Klink, A. et al: The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability. Hum. Molec. Genet. vol. 4, 869-878, 1995.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  PRKY Protein, P82-35G


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