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FGFR3 (K650E), Active

Recombinant human FGFR3 (K650E) (397-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. F06-12CG


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Catalog No. Pack Size Price (USD)
F06-12CG-05 5 ug $226
F06-12CG-10 10 ug $325
F06-12CG-BULK BULK Contact Us  


Overview:

Fibroblast growth factor receptor 3 (FGFR3) is part of a family of fibroblast growth factor receptors that share similar structure and function. FGFR3 plays a role in several important cellular processes, including regulation of cell growth and division, determination of cell fate, formation of blood vessels, wound healing and embryo development (1). FGFR3 is involved in the development and maintenance of bone and brain tissue. Mutations in FGFR3 have been implicated in causing bladder cancer, cancer of white blood cells (multiple myeloma) and cervical cancer (2).


Gene Aliases:

ACH, CEK2, JTK4, CD333, HSFGFR3EX


Genbank Number:


References:


1. Chen, L. and Deng, C.X. Roles of FGF signaling in skeletal development and human genetic diseases. Front Biosci. 2005; 1(10):1961-1976.

2. Mhawech-Fauceglia, P. et al. 2006. FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer. Eur. J. Surg. Oncol. 2006; 32(2):231-237.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73 kDa



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases


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