RIP1 kinase inhibitor
Catalog No. R07-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| R07-901-10 | 10 mg | $75 | |
| R07-901-50 | 50 mg | $225 | |
| R07-901-BULK | BULK | Contact Us |
Overview:
Inhibits cellular necroptosis a non-apoptotic cell death pathway which leads to necrosis (EC50 = 494 nM) (1). Inhibits receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM) the key upstream kinase in the necroptosis activation pathway (2,3). Reduces ischemic brain injury in a mouse model of stroke1 and inhibits myocardial death (4).
References:
1. A Degterev et al. Nat. Chem. Biol. 2005 1:112
2. A Degterev et al. Nat. Chem. Biol. 2008 4:313
3. A Linkermann et al. Kidney Int. 2012 81:751
4. CC Smith et al. Cardiovasc. Drugs Ther. 2007 21:227
CAS Registry Number:
4311-88-0
Molecular Formula:
C13H13N3OS
Appearance:
Yellow powder
Melting Point:
N/A
Molecular Weight:
259.3
Purity:
>98% (TLC: 1:9, CH3OH:CH2Cl2; Rf=0.6); NMR (Conforms)
Solubilization:
May be dissolved DMSO (25 mg/ml); or ethanol (6 mg/ml)
Aliases:
1. 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
2. Methylthiohydantoin-DL-tryptophan
Storage and Stability:
Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
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There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases
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