NDR2 or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family. NDR2 is regulated by Mob proteins and is also known as serine/threonine kinase 38 like (STK38L) (1). NDR2 act as novel pro-apoptotic kinase that is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis (2). NDR2 is mainly involved in the regulation of structural processes in differentiating and mature neuronal cells and it is highly expressed with highest levels observed in the thymus (3).
1. Millward, T. et.al: Molecular cloning and characterization of a conserved nuclear serine (threonine) protein kinase. Proc. Nat. Acad. Sci. 92: 5022-5026, 1995.
2. Vichalkovski A. et.al: NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol. 2008 Dec 9;18(23):1889-95.
3. Devroe E. et.al: Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J. Biol. Chem. 279:24444-24451, 2004.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cancer, Cell Cycle, Inflammation, Ser/Thr Kinases