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NDR2, Active

Recombinant full-length human NDR2 (STK38L) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S50-10G


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Catalog No. Pack Size Price (USD)
S50-10G-05 5 ug $226
S50-10G-10 10 ug $325
S50-10G-BULK BULK Contact Us  


Overview:

NDR2 or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family. NDR2 is regulated by Mob proteins and is also known as serine/threonine kinase 38 like (STK38L) (1). NDR2 act as novel pro-apoptotic kinase that is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis (2). NDR2 is mainly involved in the regulation of structural processes in differentiating and mature neuronal cells and it is highly expressed with highest levels observed in the thymus (3).


Gene Aliases:

KIAA0965; STK38L


Genbank Number:


References:


1. Millward, T. et.al: Molecular cloning and characterization of a conserved nuclear serine (threonine) protein kinase. Proc. Nat. Acad. Sci. 92: 5022-5026, 1995.

2. Vichalkovski A. et.al: NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol. 2008 Dec 9;18(23):1889-95.

3. Devroe E. et.al: Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. J. Biol. Chem. 279:24444-24451, 2004.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~82 kDa



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cell Cycle, Inflammation, Ser/Thr Kinases


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