Overview:

RhoA is a member of the Rho gene family that interacts with protein kinases and serves as a target of activated GTPase. RhoA plays an important role in the initial events of cell protrusion, whereas Rac1 and Cdc42 activate pathways implicated in reinforcement and stabilization of newly expanded protrusions. Rho mediates corneal epithelial migration in response to external stimuli by regulating the organization of the actin cytoskeleton (1). The inhibition of RhoA signaling is required for both vaccinia morphogenesis and virus-induced cell motility. Vaccinia inhibits RhoA signalling using the viral protein F11 and this can enhance the spread of infection (2).

Gene Aliases:

ARH12; ARHA; RHO12; RHOH12

Genbank Number:

NM_001664

References:

1. Wu, K. Y.et.al: Local translation of RhoA regulates growth cone collapse. Nature 436: 1020-1024, 2005.

2. Valderrama, F.et.al: Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling. Science 311: 377-381, 2006.