Overview:

UBE2I or ubiquitin-conjugating enzyme E2I is a member of the E2 ubiquitin-conjugating enzyme family which is required for post-replicative DNA damage repair. UBE21 also known as UBC9, plays a role DNA damage repair via interaction with WT1, which is able to impose a block in cell cycle progression in eukaryotic cells (1). Listeria and probably other pathogens, dampens the host response by decreasing the sumoylation level of proteins critical for infection by targeting UBC21, an essential enzyme of the SUMO pathway. UBC21 and the SUMO pathway are crucial for proper nuclear architecture, accurate chromosome segregation, and embryonic viability (2).

Gene Aliases:

C358B7.1; P18; UBC9

Genbank Number:

NM_003345

References:

1. Wang, Z.-Y. et.al: Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. J. Biol. Chem. 271: 24811-24816, 1996.

2. Nacerddine, K. et.al The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev. Cell 9: 769-779, 2005.