Overview:

Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) belongs to the ubiquitin-conjugating enzyme family of the ubiquitin-proteasome pathway, facilitating the transfer of activated ubiquitin from ubiquitin-activating enzyme to target proteins with the help of ubiquitin-protein ligases. It specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases and does not function with most RING-containing E3 ubiquitin-protein ligases. Catalyzes 'Lys-11'-linked polyubiquitination in vitro.

Gene Aliases:

E2-F1; L-UBC; UBCH7; UbcM4

Genbank Number:

NM_003347

References:

1. Nuber U, et al: Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. J Biol Chem. 1996 271:2795-800

2. David Y, et al: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J Biol Chem. 2010 19;285:8595-604.

3. http://www.uniprot.org/uniprot/P68036