Home    >   Primary Antibodies

Anti-Stathmin

Rabbit Polyclonal Antibody
Catalog No. S71-363R


Shop Online



Catalog No. Pack Size Price (USD)
S71-363R-100 100 ug $325
S71-363R-BULK BULK Contact Us  


Overview:

Stathmin is a ubiquitous, highly conserved protein present in the cytoplasm in a variety of unphosphorylated and phosphorylated forms. Stathmin functions as an intracellular relay integrating regulatory signals of the cellular environment (1). Stathmin is involved in the regulation of the microtubule filament system. Stathmin binds tubulin in a ternary complex, with 2 tubulins for every stathmin and this complex interferes with microtubule dynamics in vitro and in vivo. Overexpression of several stathmin mutants suggest that stathmin induces depolymerization of interphase and mitotic microtubules in its unphosphorylated state, but is inactivated by phosphorylation in mitosis (2).

References:


1. Sobel, A. Stathmin: a relay phosphoprotein for multiple signal transduction? Trends Biochem. Sci. 16: 301-305, 1991.

2. Gavet, O. et al: The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J. Cell Sci. 111: 3333-3346, 199.


Specificity:

Recognizes the Stathmin protein


Cross Reactivity:

Human and Mouse


Host / Isotype / Clone#:

Rabbit, IgG


Immunogen:

Stathmin antibody was raised against a 20 amino acid synthetic peptide from near the carboxy terminus of human Stathmin


Purification:

Affinity chromatography


Stability:

Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Sample Data:

Western blot analysis of Stathmin in EL4 cell lysate with Stathmin antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.


Sample Data:

Immunohistochemistry of Stathmin in human brain tissue with Stathmin antibody at 2.5 ug/mL.



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Invasion/Metastasis, Neurobiology



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox