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STK39 (STLK3), Active

Recombinant full-length human STK39 (STLK3) was expressed using baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. S51-10H


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Catalog No. Pack Size Price (USD)
S51-10H-05 5 ug $226
S51-10H-10 10 ug $325
S51-10H-BULK BULK Contact Us  


Overview:

STK39 (also known as serine threonine kinase 39) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress (1). STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure (2).


Gene Aliases:

STK39; STLK3; DCHT; DKFZp686K05124; PASK; SPAK


Genbank Number:


References:


1. Johnston, A. M. et.al: SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene 19: 4290-4297, 2000.

2. Chen LY. et.al: STK39 is an independent risk factor for male hypertension in Han Chinese. Int J Cardiol, 2010 Oct 1.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~63 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases


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