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MARK2, Active

Recombinant full-length human MARK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M44-10G


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Catalog No. Pack Size Price (USD)
M44-10G-05 5 ug $226
M44-10G-10 10 ug $325
M44-10G-BULK BULK Contact Us  


Overview:

MARK2 or microtubule affinity-regulating kinase 2 is a member of the Par-1 family of serine/threonine protein kinases. MARK2 is an important regulator of cell polarity in epithelial and neuronal cells and controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins (1). MARK2 is a key target of H. pylori CagA in the disorganization of gastric epithelial architecture underlying mucosal damage, inflammation, and carcinogenesis (2). MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation. MARK2 function in the establishment of T cell polarity following engagement to an APC.


Gene Aliases:

EMK1, PAR-1, MGC99619


Genbank Number:


References:


1. Yoshimura, Y. et.al: Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons. . J. Neurosci. 27:13098-13107, 2010

2. Saadat, I. et.al: Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 447: 330-333, 2007.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~114 kDa



There are no related publications available for this product.


RESEARCH AREAS

Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


RELATED PRODUCTS


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