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ACK, Active

Recombinant human ACK (110-476) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A05-11G


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Catalog No. Pack Size Price (USD)
A05-11G-05 5 ug $226
A05-11G-10 10 ug $325
A05-11G-BULK BULK Contact Us  


Overview:

ACK is a tyrosine kinase that binds CDC42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42Hs (1). Overexpression of ACK in cancer cell lines of epithelial origin increases cellular motility and invasiveness. In a mouse model, ACK overexpression enhances the ability of a human breast cancer cell line to metastasize to the lung and increased mortality (2). Ligand stimulation of alpha-3 beta-1 integrin leads to activation of ACK which then enhances p130CAS phosphorylation and activation of RAC.


Gene Aliases:

TNK2, ACK1, FLJ44758, FLJ45547, p21cdc42Hs


Genbank Number:


References:


1.Manser, E. et al: A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 363: 364-367, 1993.

2.van der Horst, E. H.; Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1. Proc. Nat. Acad. Sci. 102: 15901-15906, 2005.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~66 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Receptor Tyrosine Kinases


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