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GRK7, Active

Full-length recombinant human GRK7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. G05-10G


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Catalog No. Pack Size Price (USD)
G05-10G-05 5 ug $226
G05-10G-10 10 ug $325
G05-10G-BULK BULK Contact Us  


Overview:

GRK7 is a member of the G protein-coupled receptor kinase subfamily and is a Ser/Thr protein kinase. GRK7 is specifically expressed in the retina and has been shown to phosphorylate cone opsins and initiate their deactivation (1). GRK7 catalyzes rhodopsin phosphorylation in a light-dependent manner. GRK7 co-localizes with GRK1 in human cone outer segments. PKA phosphorylates GRK7 at Ser(23) and Ser(36) in vitro and phosphorylation of GRK7 by PKA reduces the ability of GRK7 to phosphorylate rhodopsin in vitro (2). Since exposure to light causes a decrease in cAMP levels in rod cells, it is proposed that phosphorylation of GRK7 by PKA occurs in the dark.


Gene Aliases:

GPRK7


Genbank Number:


References:


1. Chen, C-K. et al: Characterization of human GRK7 as a potential cone opsin kinase. Molec. Vision 7: 305-313, 2001.

2. Horner, T J. et al: Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities. J Biol Chem. 2005 Aug 5;280(31):28241-50.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~89 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Metabolic Disorder, Neurobiology, Ser/Thr Kinases


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