EGFR kinase inhibitor
Catalog No. E10-900C
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E10-900C-10 | 10 mg | $55 | |
E10-900C-100 | 100 mg | $120 | |
E10-900C-BULK | BULK | Contact Us |
Overview:
Potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM) (1). Potent inhibitor of mutant JAK2-V617F (2). Weaker inhibitor of ErbB-2 kinase (Ki = 1 uM) ErbB-4 kinase (Ki = 1.5 uM) (3).
References:
1. JD Moyer et al. Cancer Res. 1997 57:4838
2. Z Li et al. J. Biol. Chem. 2007 282:3428
3. ER Wood et al. Cancer Res. 2004 64:6652
CAS Registry Number:
183319-69-9
Molecular Formula:
C22H23N3O4 ∙ HCl
Appearance:
White to off-white powder
Melting Point:
N/A
Molecular Weight:
429.9
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (18 mg/ml, warm)
Aliases:
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine, hydrochloride
Storage and Stability:
Storage, Stability and Shipping
Molecular Structure:
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases
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