Recombinant human KDM1A (172-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K421-31G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K421-31G-20 | 20 ug | $215 | |
| K421-31G-50 | 50 ug | $435 | |
| K421-31G-BULK | BULK | Contact Us |
Overview:
KDM1A or lysine (K)-specific demethylase 1A is a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain that is a component of several histone deacetylase complexes and act as a histone demethylase. (1) H3K4 histone demethylase activity of KDM1A is partly responsible for the repressive activity of TAL1 and restricts TAL1 function in hematopoiesis (1). KDM1A plays an essential role for CoREST in demethylation of H3K4 both in vitro and in vivo (2).
Gene Aliases:
AOF2; BHC110; LSD1; KIAA0601
Genbank Number:
References:
1. Hu, X. et.al : LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Nat. Acad. Sci. 106: 10141-10146, 2009.
2. Lee, M. G. et.al : An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 437: 432-435, 2005
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~100 kDa
Cancer, Cell Cycle, Inflammation
Anti-Methylated Lysine (Tri- epsilon-N-methyl), FITC Conjugated, L95-67CR
KDM5C Protein, K425-31CG
KDM4B Protein, K424-31BG
KDM4C Protein, K424-31CG
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