Recombinant full-length human CAMK2beta was expressed by baculovirus in Sf9 cells using an N-terminal His tag.
Catalog No. C12-10H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C12-10H-05 | 5 ug | $226 | |
C12-10H-10 | 10 ug | $325 | |
C12-10H-BULK | BULK | Contact Us |
Overview:
CAMK2β belongs to the serine/threonine protein kinase family and to the type II multifunctional Ca(2+)/calmodulin-dependent protein kinase subfamily. CAMK2β showed wide tissue and cell distribution, and one of CAMK2β variant predominated in adult brain (1). The ratio of CAMK2α and CAMK2β protein levels were inversely related during activity in hippocampal neurons (2). CAMK2β is a prominent kinase in the central nervous system and may function in long-term potentiation and neurotransmitter release.
Gene Aliases:
CAMKB, CAM2, CAMK2, MGC29528
Genbank Number:
References:
1. Tombes, R. M. et al: Identification of novel human tumor cell-specific CaMK-II variants. Biochim. Biophys. Acta 1355: 281-292, 1997.
2. Thiagarajan, T. C. Et al: Alpha- and beta-CaMKII: inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron 36: 1103-1114, 2002.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~58 kDa
A Thorne Curtis et al., Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α Nature Chemical Biology November 2010 10.1038/nchembio.453
Caroccia Alessia et al., N-(Phenoxyalkyl)amides as MT(1) and MT(2) ligands: antioxidant properties and inhibition of Ca(2+)/CaM-dependent kinase II. Bioorganic & Medicinal Chemistry February 2013 10.1016/j.bmc.2012.12.017
Cipolletta E et al., Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase Endocrinology June 2010 10.1210/en.2009-1248
A. Witczak Carol et al., CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism June 2010 10.1152/ajpendo.00659.2009
Illario Maddalena et al., Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake Cellular signalling January 2007 10.1016/j.cellsig.2009.01.022
C Bruno et al., The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca(2+)/calmodulin-dependent kinase II. European Journal of Medicinal Chemistry June 2016 10.1016/j.ejmech.2016.03.045
Monterrey Gomez et al., Characterization of a selective CaMKII peptide inhibitor European Journal of Medicinal Chemistry April 2013 10.1016/j.ejmech.2012.12.053
Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases
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