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Moesin Protein

Recombinant human Moesin (410-end) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. M52-55G


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Catalog No. Pack Size Price (USD)
M52-55G-50 50 ug $105
M52-55G-200 200 ug $160
M52-55G-BULK BULK Contact Us  


Overview:

Moesin (or membrane-organizing extension spike protein) belongs to ERM family that modulates epithelial integrity by regulating cell-signalling events that affect actin organization and polarity (1). The effects of Moesin on epithelial cells appear to result from inhibition of Rho signaling. ERM proteins serve a structural role in linkage of the cytoskeletion to the plasma membrane and the rescue of cells lacking Moesin by modulation of Rho signaling indicates that inhibition of Rho activity may be a more critical function of Moesin. The negative feedback loop produced by Rho's activation of ERM may be an important mechanism that prevents the excessive migratory and invasive properties characteristic of metastatic cancer cells (2).


Gene Aliases:

MSN


Genbank Number:


References:


1. Speck, O. et al: Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature. 2003;421(6918):83-7.

2. Lankes, W.T. et akl: Moesin: a member of the protein 4.1-talin-ezrin family of proteins Proc. Natl. Acad. Sci. U S A. 1991;88(19):8297-301.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~50 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Inflammation, PKA/PKC Pathway



SIGNALCHEM BIOTECH INC.


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