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RanGAP1 Protein

Recombinant human RanGAP1 (418-end) was expressed in E. coli cells using an N-terminal his tag.
Catalog No. R298-31H


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Catalog No. Pack Size Price (USD)
R298-31H-20 20 ug $215
R298-31H-50 50 ug $435
R298-31H-BULK BULK Contact Us  


Overview:

RANGAP1, Ran GTPase activating protein 1, is the control substrate, which produces a single SUMO modification during SUMOylation (1). As a GTPase activator, RANGAP1 is involved in nuclear envelope assembly and nuclear transport through interacting with Ras-related nuclear protein 1(RAN) and regulating GTP-binding and exchange (2). Also, abnormal localization of RanGAP1 was found in cortex of the patients with Huntington’s disease (3)


Gene Aliases:

Fug1; RANGAP; SD


Genbank Number:


References:


1. Joseph J., et.al. SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. J. Cell Biol. 156:595-602, 2002.

2. Swaminathan S., et.al. RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. J. Cell Biol. 164:965-971, 2004.

3. Gasset-Rosa F., et.al. Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron. Apr 5; 94 (1):48-57, 2017.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~20 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Neurobiology



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