Home   >    Reagents   >   Assay Substrates

LC20 Protein

Recombinant full-length mouse LC20 was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. M89-54G


Shop Online



Catalog No. Pack Size Price (USD)
M89-54G-50 50 ug $105
M89-54G-200 200 ug $160
M89-54G-BULK BULK Contact Us  


Overview:

LC20 is the myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads (1). LC20 protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for LC20 and the deduced 172-amino acid protein is highly conserved, with only 3 differences between the human and chicken proteins. Light chain phosphorylation causes the folded monomeric form of myosin to extend and assemble into filaments. This observation established the involvement of the LC20 in conformational transitions of smooth muscle myosin (2).


Gene Aliases:

MYL9, MGC3505, MLC2, MRLC1, MYRL2


Genbank Number:


References:


1. Wagner, P D. et al: Regulation of the actin-activated ATPase of aorta smooth muscle myosin. J Biol Chem. 1986 Jun 15;261(17):7778-83.

2. Trybus, K M. et al: The regulatory light chain is required for folding of smooth muscle myosin. J Biol Chem. 1988 Nov 5;263(31):16485-92.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~45 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease


RELATED PRODUCTS


  MLCK, Active, M62-11G

  MYLK2, Active, M63-10H

  DAPK2, Active, D02-10G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox