JNK2 is a member of the JNK family that acts as an integration point for multiple biochemical signals and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK2 targets specific transcription factors, and mediates immediate-early gene expression in response to various cell stimuli. Both UV radiation and the proinflammatory cytokine TNFα can induce JNK2. JNK2 play a main role in the regulation of regional specific apoptosis (1) during early brain development and providing protection against autoimmune diabetes (2).
MAPK9, SAPK, p54a, JNK2A, JNK2B, PRKM9, JNK-55, JNK2BETA, p54aSAPK, JNK2ALPHA
1. Kuan, C. et.al: The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22: 667-676, 1999.
2. Jaeschke, A. et.al: Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc. Nat. Acad. Sci. 102: 6931-6935, 2005.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Meter M Van et al., JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports September 2016 10.1016/j.celrep.2016.08.006
Puri Puneet et al., Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease Gastroenterology October 2006 10.1053/j.gastro.2007.10.039
Hong Park Sun et al., IRAK4 as a Molecular Target in the Amelioration of Innate Immunity?Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid Journal of Immunology November 2014 10.4049/jimmunol.1402101
Selvaraja Nagarathinam et al., Extracellular Signal-Regulated Kinase Signaling Regulates the Opposing Roles of JUN Family Transcription Factors at ETS/AP-1 Sites and in Cell Migration Molecular and Cellular Biology January 2015 10.1128/MCB.00982-14
Ines Cervigni Romina et al., JNK2 controls fragmentation of the Golgi complex and G2/M transition trough phosphorylation of GRASP65 Journal of Cell Science June 2015 10.1242/jcs.164871
Nelson KJ et al., H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes Journal of Biological Chemistry September 2018 10.1074/jbc.RA118.004613
Prakasam A et al., JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1 Cell Death & Disease July 2014 10.1038/cddis.2014.316
Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, JNK/SAPK Pathway, Neurobiology, NfkB Pathway, Ser/Thr Kinases