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NUAK1, Active

Recombinant full-length human NUAK1 (ARK5) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N19-10G


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Catalog No. Pack Size Price (USD)
N19-10G-05 5 ug $226
N19-10G-10 10 ug $325
N19-10G-BULK BULK Contact Us  


Overview:

NUAK1 or SNF1/AMP kinase-related kinase (SNARK) is a member of the NUAK family of SNF1-like kinase 1 that is also known as AMPK-related protein kinase 5 (ARK5). ARK5 is a tumor cell survival factor that is activated by AKT and acts as an ATM kinase under conditions of nutrient starvation (1). NUAK1 is highly expressed in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung, and liver. NUAK1 is involved in tolerance to glucose starvation and suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR (2).


Gene Aliases:

ARK5; KIAA0537


Genbank Number:


References:


1. Suzuki, A. et.al: Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. J. Biol. Chem. 278: 48-53, 2003.

2. Lizcano J.M. et.al: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 23:833-843, 2004.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~122 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cellular Stress, Metabolic Disorder, Ser/Thr Kinases


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