Recombinant human WHSC1L1 (NSD3) (1038-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N378-31G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N378-31G-20 | 20 ug | $314 | |
| N378-31G-50 | 50 ug | $545 | |
| N378-31G-BULK | BULK | Contact Us |
Overview:
Histone-lysine N-methyltransferase NSD3 or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1) is a nuclear receptor binding SET domain (NSD) protein that belongs to a family of three histone methyltransferases including NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
Gene Aliases:
NSD3, DC28, FLJ20353, pp14328
Genbank Number:
References:
1. Kim SM, et al: Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity. Biochem Biophys Res Commun. 2006 Jun 23;345(1):318-23.
2. Morishita M, et al: Cancers and the NSD family of histone lysine methyltransferases. Biochim Biophys Acta. 2011 Dec;1816(2):158-63.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~72 kDa
There are no related publications available for this product.
Cancer, Cell Cycle
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