p38 MAP kinase inhibitor
Catalog No. M39-900B
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M39-900B-10 | 10 mg | $75 | |
| M39-900B-50 | 50 mg | $300 | |
| M39-900B-BULK | BULK | Contact Us |
Overview:
Potent and selective p38 MAP kinase inhibitor acting at the ATP site (1). Selectively inhibits the p38alpha and beta isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38beta2 respectively) (2). Effectively blocks LPS-induced gene expression in monocytes (3). Induces apoptosis (4). Cell permeable.
References:
1. PR Young et al. J. Biol. Chem. 1997 272:12116
2. SP Davies et al. Biochem. J. 2000 351:95
3. CL Manthey et al. J. Leukoc. Biol. 1998 64:409
4. S Nemoto et al. J. Biol. Chem. 1998 273:16415
CAS Registry Number:
152121-30-7
Molecular Formula:
C20H14N3OF
Appearance:
Yellow powder
Melting Point:
277-278oC
Molecular Weight:
331.4
Purity:
>98% (TLC: 10% CH3OH in CH2Cl2, Rf=0.25); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (30mg/ml)
Aliases:
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl] phenol
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.
Molecular Structure:
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There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases
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