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MEK4 (MAP2K4), Active

Recombinant full-length human MEK4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M05-10G


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Catalog No. Pack Size Price (USD)
M05-10G-05 5 ug $226
M05-10G-10 10 ug $325
M05-10G-BULK BULK Contact Us  


Overview:

Mitogen-activated protein kinase kinase 4 (MEK4 or MKK4) is dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MKK4 preferentially phosphorylates the tyrosine residue of JNKs. Mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MKK4 is important for carcinogenesis, a loss-off-function mutation in MKK4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MKK4.


Gene Aliases:

MAP2K4, JNKK1, MAPKK4, MKK4, PRKMK4, SKK-1, SEK1


Genbank Number:


References:


1. Lin A, et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science. 268: 286-90, 1995.

2. Wang L, et al. Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors. Oncogene. 23:5978-85, 2004.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~71 kDa



Product Datasheets



RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


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