Mitogen-activated protein kinase kinase 4 (MEK4 or MKK4) is dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MKK4 preferentially phosphorylates the tyrosine residue of JNKs. Mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MKK4 is important for carcinogenesis, a loss-off-function mutation in MKK4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MKK4.
MAP2K4, JNKK1, MAPKK4, MKK4, PRKMK4, SKK-1, SEK1
1. Lin A, et al. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science. 268: 286-90, 1995.
2. Wang L, et al. Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors. Oncogene. 23:5978-85, 2004.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Puri Puneet et al., Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease Gastroenterology October 2006 10.1053/j.gastro.2007.10.039
Parizek Petra et al., Designed Ankyrin Repeat Proteins (DARPins) as Novel Isoform-Specific Intracellular Inhibitors of c-Jun N-Terminal Kinases ACS Chemical Biology November 2012 10.1021/cb3001167
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases