Protein Kinase p70 (S6K) inhibitor
Catalog No. R21-901
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This bis indolylmaleimide derivative is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR1. Does not inhibit PKC (at concentrations <100 µM) and therefore may also be used as a negative control for bisindolylmaleimide PKC inhibitors2 such as GF 109203X3 and other structurally related inhibitors4
1. N Marmy-Conus et al. FEBS Lett. 2002 519:135
2. CS Harmon et al. Skin Pharmacol. 1997 10:71
3. D Toullec et al. J. Biol. Chem. 1991 266:15771
4. PD Davis et al. J. Med. Chem. 1992 35:177
CAS Registry Number:
>98% (HPLC, TLC); NMR (conforms)
May be dissolved in DMSO (35 mg/ml); or ethanol (9 mg/ml)
1-Methyl-3,4-bis(indol-3-yl)maleimide; Bisindolylmaleimide V; BIM V
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
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AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder, Ser/Thr Kinases