Catalog No. M34-901
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Inhibits JNK2 and JNK3 via binding to the ATP binding domain. Displays little or no activity against JNK1, p38 and a panel of 30 other kinases1.
1. RM Angell et al. Bioorg. Med. Chem. Lett. 2007 17:1296
CAS Registry Number:
>98% (TLC); NMR (Conforms)
May be dissolved in DMSO (13mg/ml); or ethanol (4 mg /ml, warm)
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.
Meter M Van et al., JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports September 2016 10.1016/j.celrep.2016.08.006
Selvaraja Nagarathinam et al., Extracellular Signal-Regulated Kinase Signaling Regulates the Opposing Roles of JUN Family Transcription Factors at ETS/AP-1 Sites and in Cell Migration Molecular and Cellular Biology January 2015 10.1128/MCB.00982-14
Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, JNK/SAPK Pathway, Neurobiology, NfkB Pathway, Ser/Thr Kinases