PI3K gamma Inhibitor with an IC50 of 8nM
Catalog No. P27-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P27-901-50 | 5 mg | $75 | |
| P27-901-250 | 25 mg | $300 | |
| P27-901-BULK | BULK | Contact Us |
Overview:
Potent and selective inhibitor of PI 3-kinase γ (PI 3-K γ), IC50 = 8nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα (1). Suppresses joint inflammation in two distinct house models (1). Ameliorates surgical brain injury (2), colitis (3), intimal hyperplasia-induced inflammatory processes (4) and renal injury/fibrosis (5) in rodent models. Orally active.
References:
1. Camps M et al. Nature Med. 2005 11:936 2. Huang L et al. J. Neurosci. 2015 35:10390 3. Peng XD et al. J. Pharmacol. Exp. Ther. 2010 332:46 4. Smirnova NF et al. J. Exp. Med. 2014 211:1779 5. Yu X et al. Sci. Rep. 2018 8:10988
CAS Registry Number:
648450-29-7
Molecular Formula:
C12H7N3O2S
Appearance:
Red powder
Melting Point:
N/A
Molecular Weight:
257.3
Purity:
>98% (TLC); NMR (conforms)
Solubility:
May be dissolved DMSO (1.5 mg/ml, warm)
Aliases:
5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
Storage and Stability:
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Inflammation, Invasion/Metastasis, p38 Pathway
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