GSK3β Inhibitor
Catalog No. G09-901D
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
G09-901D-5 | 5 mg | $120 | |
G09-901D-BULK | BULK | Contact Us |
References:
1. Schmöle A-C et al. Bioorg. Med. Chem. 2010 18:6785 2. Wang T et al. Biochem. Cell Biol. 2019 97:702 3. Chen X et al. Front. Pharmacol. 2020 10:1528 4. Menzel-Severing J et al. Sci. Rep. 2018 8:10268
CAS Registry Number:
1129669-05-1
Molecular Formula:
C22H20FN3O2
Appearance:
Yellow powder
Molecular weight:
377.4
Purity:
>98% (HPLC); NMR (conforms)
solubility:
May be dissolved DMSO (50 mg/ml)
Storage and Stability:
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.
Scientific background:
A potent and selective inhibitor of glycogen synthase kinase 3β (GSK-3β) IC50=53 nM which induces neuronal differentiation (1). Activates the Wnt-β-catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models (2). Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone (3). Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation (4).
Molecular structure:
Aliases:
3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
There are no related publications available for this product.
Cancer, Cell Cycle
STAY CONNECTED
Fax: 1-604-232-4601