IkB Kinase Inhibitor
Catalog No. I03-901B
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
I03-901B-50 | 50 mg | $80 | |
I03-901B-250 | 250 mg | $330 | |
I03-901B-BULK | BULK | Contact Us |
References:
1. Kwok BH et al. Chem. Biol. 2001 8:759 2. Zhao L et al. Nutr. Rev. 2011 69:310 3. Hwang D et al. Biochem. Biophys. Res. Commun. 1996 226:810 4. Groenewegen WA & S Heptinstall J. Pharm. Pharmacol. 1990 42:55 5. Pareek A et al. Pharmacogn. Rev. 2011 5:103 6. Gopal YNV et al. Chem. Biol. 2007 14:813
CAS Registry Number:
20554-84-1
Molecular Formula:
C15H20O3
Appearance:
White powder
Melting point:
N/A
Molecular weight:
248.3
Purity:
>98% (TLC); NMR (conforms)
solubility:
May be dissolved in DMSO (100 mg/ml); or ethanol (up to 20 mg/ml)
Storage and Stability:
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
Scientific background:
Parthenolide is a natural product that inhibits NF-κB signaling via two mechanisms: direct inhibition of IκB kinase, and prevention of NOD2 dimerization (1,2). It inhibited expression of COX-2 and proinflammatory cytokines, TNF alpha and IL-1 in lipopolysaccharide (LPS)-stimulated macrophages (3). Parthenolide demonstrates antisecretory (4) and spasmolytic (5) activities in vivo. It also causes proteasomal degradation of HDAC1 (but not other class I/II HDACs), and cell death through the ATM pathway (6).
Molecular structure:
Aliases:
Sesquiterpene lactone found in feverfew (Tanacetum parthenium)
There are no related publications available for this product.
Cell Cycle, Inflammation
STAY CONNECTED
Fax: 1-604-232-4601