A3 adenosine receptor antagonist; Aurora A/B/C inhibitor
Catalog No. A28-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A28-900-01 | 1 mg | $60 | |
| A28-900-05 | 5 mg | $120 | |
| A28-900-BULK | BULK | Contact Us |
References:
1. Chen S et al. J. Am. Chem. Soc. 2004 126:410 2. Chen S et al. Proc. Natl. Acad. Sci USA 2007 104:10482 3. Perreira M et al. J. Med. Chem. 2005 48:4910 4. D’Alise AM et al. Mol. Cancer Ther. 2008 7:1140. 5. Qin HX et al. Cytotechnology 2013 65:643-53.
CAS Registry Number:
656820-32-5
Molecular Formula:
C21H27N7O
Appearance:
Off-white powder
Molecular weight:
393.5
Purity:
>98% (HPLC, TLC); NMR (conforms)
solubility:
May be dissolved DMSO (7 mg/ml)
Storage and Stability:
Store desiccated as supplied at -20°C. Store solutions at -20°C for up to 3 months.
Scientific background:
Induces differentiated myogenic-lineage-committed cells to become multipotent mesenchymal progenitor cells (1, 2). Acts as a selective human A3 adenosine receptor antagonist (Ki=0.66 µM) (3). Cell permeable. Reversine is also a known ATP-competitive Aurora kinase inhibitor with nanomolar IC50s for Aurora A, Aurora B and Aurora C, as well as a monopolar spindle 1 (Mps1) kinase inhibitor and mitotic spindle assembly checkpoint (SAC) inhibitor.
Molecular structure:
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Aliases:
2-(4-Morpholinoanilino)-6-cyclohexylaminopurine
There are no related publications available for this product.
Gastrointestinal Diseases , PKA/PKC Pathway
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