CAS Registry Number:

745833-23-2

Molecular Formula:

C19H12F4N4O2

Appearance:

White Powder

Melting point:

N/A

Molecular weight:

404.3

Purity:

>98% (HPLC); NMR (conforms)

solubility:

May be dissolved DMSO (40 mg/ml); or ethanol (2 mg/ml)

Storage and Stability:

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

Scientific background:

A potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively) (1). Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood (1). Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 µM (2). Provides only modest clinical efficacy in rheumatoid arthritis (3, 4). Delays platelet lesions and leads to better maintenance of stored platelets (5).

Molecular structure:

Aliases:

6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide