p38 MAPK Inhibitor
Catalog No. M39-900D
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M39-900D-05 | 5 mg | $55 | |
M39-900D-25 | 25 mg | $230 | |
M39-900D-BULK | BULK | Contact Us |
References:
1. Goldstein DM et al. J. Med. Chem. 2010 53:2345 2. Kuliopulos A et al. Thromb. Haemostasis 2004 92:1387 3. Damjanov N et al. Arthrit. Rheumat. 2009 60:1232 4. Ding C Curr. Opin. Investig. Drugs 2006 7:1020 5. Scripchenko A et al. PLoS One 2013 8(8)e:70732
CAS Registry Number:
745833-23-2
Molecular Formula:
C19H12F4N4O2
Appearance:
White Powder
Melting point:
N/A
Molecular weight:
404.3
Purity:
>98% (HPLC); NMR (conforms)
solubility:
May be dissolved DMSO (40 mg/ml); or ethanol (2 mg/ml)
Storage and Stability:
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
Scientific background:
A potent and selective inhibitor of p38 MAP kinases, p38α MAPK and p38β (KD = 3.7 and 17 nM respectively) (1). Inhibits IL-6, IL-1β and TNFα production in LPS-primed blood (1). Inhibits p38 in platelets stimulated by thrombin, collagen or thromboxane agonist U-46619 at 1 µM (2). Provides only modest clinical efficacy in rheumatoid arthritis (3, 4). Delays platelet lesions and leads to better maintenance of stored platelets (5).
Molecular structure:
Aliases:
6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
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