CHK2 inhibitor
Catalog No. C48-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C48-901-05 | 5 mg | $75 | |
| C48-901-25 | 25 mg | $270 | |
| C48-901-BULK | BULK | Contact Us |
Overview:
A highly selective inhibitor of Chk2 (IC50=15 nM). Displays <25% inhibition of 35 other kinases at 10 uM) (1). It possesses potent radioprotective activity and prevents apoptosis of human T-cells subjected to ionizing radiation (EC50= 3-7.6 μM) (1). It is a useful tool for determining the role of Chk2 in cellular signaling (2).
References:
1. K L Arienti et al. J. Med. Chem. 2005 48:1873
2. Y Pereg et al. Mol. Cell. Biol. 2006 26:6819
CAS Registry Number:
516480-79-8
Molecular Formula:
C20H14ClN3O2
Appearance:
Off white solid
Melting Point:
N/A
Molecular Weight:
363.8
Purity:
≥98% (TLC; 1:1 ethylacetate: hexane; Rf=0.17); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (20 mg/ml); or Ethanol (20 mg/ml)
Aliases:
1. 2-(4-(4-chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
2. Chk2 Inhibitor II
Storage and Stability:
Storage, Stability and Shipping
Molecular Structure:
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There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases
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