ALK inhibitor
Catalog No. A09-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A09-900-05 | 5 mg | $75 | |
| A09-900-25 | 25 mg | $315 | |
| A09-900-BULK | BULK | Contact Us |
Overview:
Potent and selective ALK4, 5 and 7 inhibitor (1,2). IC50=45, 12, 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ (2). Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency (3). Together with AMI-5 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts (4). Active in rat models. Cell permeable
References:
1. J Vogt et al. Cell Signal. 2011 23:1831
2. M Tojo et al. Cancer Sci. 2012 96:791
3. W Li et al. Cell Stem Cell 2009 4:16
4. X Yuan et al. Stem Cells 2011 29:549
CAS Registry Number:
909910-43-6
Molecular Formula:
C25H19N5S
Appearance:
Light Yellow powder
Melting Point:
N/A
Molecular Weight:
421.5
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (20mg/ml)
Aliases:
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Storage and Stability:
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.
Molecular Structure:
|
AKT/PKB Pathway, Angiogenesis, Cancer, Cardiovascular Disease, JAK/STAT Pathway, Neurobiology, Ser/Thr Kinases
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Kranenburg O et al., Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures. Scientific Reports January 2019 10.1038/s41598-018-37316-w
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