PDGFR Inhibitor
Catalog No. P12-900
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P12-900-05 | 5 mg | $90 | |
| P12-900-25 | 25 mg | $390 | |
| P12-900-BULK | BULK | Contact Us |
Overview:
A potent inhibitor of PDGF receptor tyrosine kinase (PDGFRalpha and beta), IC50=1 µM (1). Also inhibits FGF receptor tyrosine kinase (2), c-kit (3) and FLT3 (4) and reverses transformation induced by activated FLT3 (5). Induces apoptosis in a small-cell lung cancer cell line (H526) (3). Cell permeable.
References:
1. M Kovalenko et al. Biochemistry 1997 36:6260
2. F Strutz et al. Kidney Int. 2001 59:579
3. G W Krystal et al. Cancer Res. 1997 57:2203
4. R Grundler et al. Blood 2003 102:646
5. KF Tse et al. Leukemia 2001 15:1001
CAS Registry Number:
146535-11-7
Molecular Formula:
C16H14N2O2
Appearance:
Off white to yellow powder
Melting Point:
N/A
Molecular Weight:
266.3
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO
Aliases:
6,7-Dimethoxy-3-phenylquinoxaline
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.
Molecular Structure:
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There are no related publications available for this product.
AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases
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