Selective CK2 inhibitor
Catalog No. K10-900C
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K10-900C-10 | 10 mg | $55 | |
| K10-900C-50 | 50 mg | $140 | |
| K10-900C-BULK | BULK | Contact Us |
Overview:
Selective CK2 inhibitor. Inhibits proliferation of Wnt-1 transfected cells and suppresses phosphorylation of beta-catenin. Ameliorates renal dysfunction at 20 mg/Kg in a rat model of glomerulonephritis. Cell permeable and active in vivo.
References:
1. J Shen et al. J. Immunol. 2001 167:4919
2. DH Song et al. J. Biol. Chem. 2000 275:23790
3. M Yamada et al. Proc. Natl. Acad. Sci. USA 2005 102:7736
CAS Registry Number:
520-36-5
Molecular Formula:
C15H10O5
Appearance:
Yellow powder
Melting Point:
345-350oC
Molecular Weight:
270.2
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (50 mg/ml)
Aliases:
4',5,7-Trihydroxyflavone
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.
Molecular Structure:
|
Artamonov MV et al., RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger Science Signaling October 2018 10.1126/scisignal.aar3924
S. Huang Bing et al., Possible role of brain salt-inducible kinase 1 in responses to central sodium in Dahl rats American Journal of Physiology - Regulatory, Integrative, and Comparative Physiology July 2012 10.1152/ajpregu.00381.2011
Frost Danielle et al., β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites PLoS One May 2011 10.1371/journal.pone.0019264
et al., Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway. Nature cell biology June 2018
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Receptor Tyrosine Kinases, Ser/Thr Kinases, WNT Signaling
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