p38 MAP kinase inhibitor
Catalog No. M39-900C
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M39-900C-05 | 5 mg | $90 | |
| M39-900C-25 | 25 mg | $360 | |
| M39-900C-BULK | BULK | Contact Us |
Overview:
A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38beta2 respectively (1). No other kinases (in a panel of 30) were significantly inhibited including p38gamma and delta at 10 uM (2). A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function (3).
References:
1. A Cuenda et al. FEBS Lett. 1995 364:229
2. SP Davies et al. Biochem. J. 2000 351:95
3. AM Badger et al. J. Pharmacol. Exp. Ther. 1996 279:1453
CAS Registry Number:
152121-47-6
Molecular Formula:
C21H16N3OSF
Appearance:
Off white powder
Melting Point:
245-247oC
Molecular Weight:
377.4
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (100 mg/ml); or Ethanol (10 mg/ml, warm)
Aliases:
4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl) imidazole
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions a -20oC for up to 3 months.
Molecular Structure:
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Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases
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et al., Transcriptional Activation of Lipogenesis by Insulin Requires Phosphorylation of MED17 by CK2 Science signaling August 2017 
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