p38 MAP kinase inhibitor
Catalog No. M39-900C
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A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38beta2 respectively (1). No other kinases (in a panel of 30) were significantly inhibited including p38gamma and delta at 10 uM (2). A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function (3).
1. A Cuenda et al. FEBS Lett. 1995 364:229
2. SP Davies et al. Biochem. J. 2000 351:95
3. AM Badger et al. J. Pharmacol. Exp. Ther. 1996 279:1453
CAS Registry Number:
Off white powder
>98% (TLC); NMR (Conforms)
May be dissolved in DMSO (100 mg/ml); or Ethanol (10 mg/ml, warm)
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions a -20oC for up to 3 months.
There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases