IGF1R inhibitor
Catalog No. I02-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| I02-901-05 | 5 mg | $120 | |
| I02-901-25 | 25 mg | $480 | |
| I02-901-BULK | BULK | Contact Us |
Overview:
Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP (1). Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM (1). Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 uM (2). Exhibits antiangiogenic activitiy (3). Attenuates intimal hyperplasia after vascular injury (4). Active in vivo.
References:
1. A Girnita et al. Cancer Res. 2004 64:236
2. A Girnita et al. Clin. Cancer Res. 2006 12:1383
3. E Menu et al. Int. J. Cancer 2007 121:1857
4. A Razuvaev et al. J. Vasc. Surg. 2007 46:108
CAS Registry Number:
477-47-4
Molecular Formula:
C22H22O8
Appearance:
White powder
Melting Point:
222-224oC
Molecular Weight:
414.4
Purity:
>97% (TLC); NMR (Conforms)
Solubilization:
Soluble in DMSO (40 mg/ml)
Aliases:
(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.
Molecular Structure:
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There are no related publications available for this product.
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