Catalog No. R15-900
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A selective inhibitor of the p70 ribosomal S6 kinase (S6K) (1). Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 uM with no activity at GSK3beta and Erk1/2 at 10 uM (2). Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K (2). Cell permeable.
1. TR Fenton et al. Int. J. Biochem. Cell Biol. 2011 43:47
2. S Li et al. Proc. Natl. Acad. Sci. USA 2010 107:3441
CAS Registry Number:
>97% (HPLC); NMR (Conforms)
May be dissolved in DMSO (1 mg/ml); DMF (3 mg/ml, warm)
4-(4-(4-(4-fluoro-3-(trifluoromethyl) phenyl)-1-methyl-1H-imidazol-2-yl) piperidin-1-yl)-1H-pyrazolo [3,4-d] pyrimidine
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 3 years. Store solutions at -20oC for up to 3 months.
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AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder