c-Raf inhibitor
Catalog No. R01-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| R01-901-05 | 5 mg | $85 | |
| R01-901-25 | 25 mg | $340 | |
| R01-901-BULK | BULK | Contact Us |
Overview:
Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50uM) with the exception of p38 (SAPK2a) (IC50=2uM) and SAPK2b (p38beta) (IC50=2uM). Induces a paradoxical >100-fold activation of c-Raf in whole cells. Induces apoptosis in a variety of cell lines. Cell permeable.
References:
1. CA Hall-Jackson et al. Chem. Biol. 1999 6:559
2. D Deming et al. J. Surg. Res. 2010 161:28
CAS Registry Number:
331771-20-1
Molecular Formula:
C23H23N3O3
Appearance:
Off white powder
Melting Point:
258-260oC
Molecular Weight:
513.6
Purity:
98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (25mg/ml)
Aliases:
3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]-benzamide
Storage and Stability:
Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20°C for up to 1 month.
Molecular Structure:
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There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, JAK/STAT Pathway, Ser/Thr Kinases
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