EGFR kinase inhibitor
Catalog No. E10-900D
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E10-900D-10 | 10 mg | $75 | |
E10-900D-50 | 50 mg | $255 | |
E10-900D-BULK | BULK | Contact Us |
Overview:
Potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM) (1). Clinically useful agent for treatment of breast cancer (2-3). Cell permeable.
References:
1. ER Wood et al. Cancer Res. 2004 64:6652
2. HA Burris et al. Oncologist 2004 9:10
3. I Chu et al. Cancer Res. 2005 65:18
CAS Registry Number:
231277-92-2
Molecular Formula:
C29H26ClFN4O4S
Appearance:
Yellow powder
Melting Point:
136-140oC
Molecular Weight:
581.1
Purity:
98% (TLC); NMR (Conforms)
Solubilization:
Soluble in DMSO (200 mg/ml)
Aliases:
1. N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
2. GW-572016
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.
Molecular Structure:
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases
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