Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Lapatinib

EGFR kinase inhibitor
Catalog No. E10-900D

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Catalog No.	Pack Size	Price (USD)
E10-900D-10	10 mg	$75
E10-900D-50	50 mg	$255
E10-900D-BULK	BULK	Contact Us

Overview:

Potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM) (1). Clinically useful agent for treatment of breast cancer (2-3). Cell permeable.

References:

1. ER Wood et al. Cancer Res. 2004 64:6652

2. HA Burris et al. Oncologist 2004 9:10

3. I Chu et al. Cancer Res. 2005 65:18

CAS Registry Number:

231277-92-2

Molecular Formula:

C₂₉H₂₆ClFN₄O₄S

Appearance:

Yellow powder

Melting Point:

136-140^oC

Molecular Weight:

581.1

Purity:

98% (TLC); NMR (Conforms)

Solubilization:

Soluble in DMSO (200 mg/ml)

Aliases:

1. N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine

2. GW-572016

Storage and Stability:

Store desiccated as supplied at -20^oC for up to 2 years. Store solutions at -20^oC for up to 1 month.

Molecular Structure:

Product Datasheets

T2257-58

There are no related publications available for this product.

RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases