FLT3/TRKA inhibitor
Catalog No. F12-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| F12-901-01 | 1 mg | $120 | |
| F12-901-05 | 5 mg | $375 | |
| F12-901-BULK | BULK | Contact Us |
Overview:
Potent and selective FLT3 inhibitor (IC50= 2.0 nM) (1,2). Suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders (3).
References:
1. M Lewis et al. Expert Opin. Investig. Drugs 2003 12:1951
2. P Chen et al. J. Biol. Chem. 2005 280:5361
3. EO Hexner et al. Blood 2008 111:5663
CAS Registry Number:
111358-88-4
Molecular Formula:
C26H21N3O4
Appearance:
White to off-white solid
Melting Point:
N/A
Molecular Weight:
439.5
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (100 mg/ml); or ethanol (20 mg/ml)
Aliases:
1. CEP-701
2. KT-5555
Storage and Stability:
Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 2 months.
Molecular Structure:
|
AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases
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