Overview:

A potent, selective and reversible ATP-competitive inhibitor of AMP-activated protein kinase (AMPK), Ki = 109 nM in the presence of ATP and absence of AMP (1). Displays no significant inhibition of JAK3, PKA, PKCtheta, SYK and ZAPK. Suppresses food intake in mice (2) and inhibits the effects of AICAR and metformin (1). It also inhibits BMP type 1 receptors ALK2, ALK3 and ALK6 (3). Promotes cardiomyogenesis in mouse embryonic stem cells (4). Induces autophagy in tumor cell lines via an AMPK-independent pathway (5). Cell permeable.

References:

1. 1. G Zhou et al. J. Clin. Invest. 2001 108:1167

2. EK Kim et al. J. Biol. Chem. 2004 279:19970

3. PB Yu et al. Nat. Chem. Biol. 2008 4:33

4. J Hao et al. PloS One 2008 3:e2904

5. L Vucicevic et al. Autophagy 2011 7:40