Catalog No. A03-901B
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Tyrosine kinase inhibitor specific for bcr-abl (IC50 = 38 nM) (1), PDGF-R (IC50 = 0.3 uM) (1) and c-kit (IC50 = 0.1 uM) (2). It is a clinically useful anti-cancer drug approved for the treatment of chronic myelogenous leukemia (3), gastrointestinal stromal tumors as well as several other cancers.
1. E Buchdunger et al. Cancer Res. 1996 56:100
2. Heinrich et et al. Blood 2000 96:925
3. M Deininger et al. Pharmacol. Rev. 2003 55:401
CAS Registry Number:
C29H31N7O · CH3SO3H
98% (TLC); NMR (Conforms)
May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml)
1. 4-[(4-Methyl-1-piperazinyl) methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl] amino]-phenyl] benzamide methanesulfonate
Storage and Stability:
Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.