VEGFR, PDGFR inhibitor
Catalog No. F11-900G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| F11-900G-10 | 10 mg | $75 | |
| F11-900G-50 | 50 mg | $210 | |
| F11-900G-BULK | BULK | Contact Us |
Overview:
A potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRbeta and Kit (Ki = 2-17 nM) (1). Also inhibits cFMS (IC50=7 nM) (2) and FLT3 (3). Potent inhibitor of angiogenesis (4). Clinically useful anticancer agent. Cell permeable.
References:
1. ED Deeks et al. Drugs 2006 66:2255
2. J Guo et al. Mol. Cancer. Ther. 2006 5:1007
3. AM O’Farrell et al. Blood. 2003 101:3597
4. R Roskoski et al. Biochem. Biophys. Res. Commun. 2007 356:323
CAS Registry Number:
341031-54-7
Molecular Formula:
C22H27FN4O2 ∙ C4H6O5
Appearance:
Orange solid
Melting Point:
N/A
Molecular Weight:
532.6
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (13 mg/ml, warm)
Aliases:
1. N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malate
2. SU-11248
Storage and Stability:
Storage, Stability and Shipping
Molecular Structure:
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There are no related publications available for this product.
Angiogenesis, Cancer, Cell Cycle, Neurobiology
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