Aurora B kinase inhibitor
Catalog No. A31-901
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A31-901-05 | 5 mg | $75 | |
| A31-901-25 | 25 mg | $220 | |
| A31-901-BULK | BULK | Contact Us |
Overview:
Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 uM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.
References:
1. C Ditchfield et al J. Cell Biol. 2003 161:267
2. F Girdler et al J. Cell Sci. 2006 119:3664
3. F H Jung et al J. Med. Chem. 2006 49:955
CAS Registry Number:
331771-20-1
Molecular Formula:
C29H31N5O4
Appearance:
White solid
Melting Point:
N/A
Molecular Weight:
513.6
Purity:
>98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (50 mg/ml)
Aliases:
(N-[4-[[6-Methoxy-7-[3-(4-morpholinyl) propoxy]-4-quinazolinyl] amino] phenyl] benzamide
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.
Molecular Structure:
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There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases
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